Model of bone disease amenable to high-throughput screening
OwnerPaul Goldsmith, Angeleen Fleminginventors
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Abstract
Model fish and use thereof for screening for agents and genetic suppressors to treat bone disease or disorders, especially in zebrafish. Induction of a disease state and visualization of the skeleton in living zebrafish. Visualization of the skeleton in vivo facilitates screening for compounds that can be used in treatment of bone disease or genetic mutations that rescue or suppress the disease phenotype.
Claims19
A fish model for bone disease, wherein a glucocorticoid is administered to medium containing embryonic fish to induce bone loss in the fish.
A fish model for screening for disease phenotype, wherein a fluorescent dye is administered to medium containing embryonic fish to allow visualization of bones, cartilage and/or joints of the fish following staining by the dye.
A method of generating a fish model for bone disease, the method comprising administering a glucocorticoid to medium containing embryonic fish to induce bone loss in the fish.
A method of generating a fish model for screening for disease phenotype, the method comprising administering a fluorescent dye to medium containing fish to allow visualization of bones of the fish following staining by the dye.
Dependencies are inferred from the claim text.