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AssigneeUniversity of Massachusetts
InventorsGary Stein, Daniel Young, Sayyed Zaidi, Amjad Javed, Andre Van Wijnen, Janet Stein, Jane Lian
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The present invention provides a method useful for analysis of punctate distribution of supramolecular complexes that are compartmentalized in nuclear microenvironments. In preferred embodiments the method provides quantitative analysis of the assembly of regulatory machinery within the context of nuclear architecture and to provide a mechanistic link with biological control. In other embodiments, the invention provides a method of identifying a molecule by parameters of its subnuclear distribution, comprising the steps of quantifying organizational parameters of domains within subnuclear distributions of a molecule; performing factor analysis on the quantified organizational parameters; performing discriminant analysis on the quantified organizational parameters; comparing the results of the factor analysis and the results of the discriminant analysis to one or more standards, thereby identifying a molecule by parameters of its subnuclear distribution.
A method for quantifying domains within a punctate distribution comprising the steps of:
A method of determining the contribution of the subnuclear organization of regulatory proteins to functional gene expression regulation, comprising the steps of:
A method of identifying a molecule by parameters of its subnuclear distribution, comprising the steps of
A method of classifying cells having a propensity for a condition, comprising the steps of
Dependencies are inferred from the claim text.