Biomaterials for guided tissue regeneration and drug delivery
OwnerKuo-Huang Hsieh, Ken-Yu Chang +3inventors
InventorsKuo-Huang Hsieh, Ken-Yu Chang, Chun-Pin Lin, Liou Horng, Yung-Hsin Lin
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Abstract
The present invention is directed to compositions and methods of using compositions comprising a scaffold with growth factors chemically immobilized thereto for inducing chondrogenesis and/or osteogenesis when implanted in vivo or osteogenesis or chondrogenesis in cultures in vitro. The compositions and methods enhance bone and cartilage growth. Also described are compositions and methods for targeted drug delivery.
Claims33
A composition for guided tissue regeneration comprising:
- a. A biodegradable scaffold;
- and
- b. At least one growth factor chemically immobilized to said biodegradable scaffold;
- wherein said composition is effective for inducing chrondogenesis or osteogenesis in vivo.
A composition for guided tissue regeneration comprising:
- a. a scaffold comprising chitosan;
- and
- b. at least one growth factor chemically immobilized to said scaffold;
- wherein said composition is effective for inducing chrondogenesis or osteogenesis in vivo.
A method of treating a bone defect comprising contacting the area of the bone defect with a scaffold which has at least one growth factor chemically immobilized thereto.
A method treating a bone defect comprising contacting the area of the bone defect with a scaffold comprising chitosan which has transforming growth factor-β1 chemically immobilized thereto.
A method treating a bone injury or defect comprising contacting the area of the bone injury with a scaffold comprising chitosan which has bone morphogenetic protein-2 chemically immobilized thereto.
A composition for guided tissue regeneration comprising:
- a. A biodegradable scaffold;
- and
- b. At least one cell adhesion molecule chemically immobilized to said scaffold;
- wherein said composition is effective for inducing chrondogenesis or osteogenesis in vivo.
A composition for guided tissue regeneration comprising:
- a. A biodegradable scaffold;
- b. a spacer molecule chemically immobilized to said scaffold;
- and
- c. at least one cell adhesion molecule chemically immobilized to said spacer molecule;
- wherein said composition is effective for inducing chrondogenesis or osteogenesis in vivo.
A composition for enhancing bone or cartilage growth comprising:
- a. a scaffold;
- and
- b. at least one stem cell transfected or transformed with at least one growth factor gene;
- wherein said stem cell is chemically immobilized to said scaffold, and further wherein said composition is effective for inducing chrondogenesis or osteogenesis in vivo.
A method of treating a bone or cartilage defect comprising contacting said bone defect with a composition comprising:
- a. a scaffold;
- and
- b. at least one stem cell transfected or transformed with at least one growth factor gene;
- wherein said stem cell is chemically immobilized to said scaffold, and further wherein said composition is effective for inducing chrondogenesis or osteogenesis in vivo.
A method of treating a bone or cartilage defect comprising:
- a. transfecting or transforming a growth factor gene into a stem cell;
- b. chemically immobilizing an anti-receptor antibody of said stem cell onto a scaffold in vitro;
- c. causing said anti-receptor antibody to interact with a cell surface receptor of said stem cell, thereby immobilizing said stem cell onto said scaffold;
- and
- d. implanting in vivo said scaffold having said immobilized stem cell onto said bone or cartilage defect.
A composition for targeted drug delivery comprising:
- a. a biodegradable nanoparticle;
- b. at least one drug chemically immobilized to said biodegradable nanoparticle;
- and
- c. and at least one anti-marker-receptor antibody chemically immobilized to said biodegradable nanoparticle.
A method of treating a tumor comprising administering to an organism a composition comprising:
- a. a biodegradable nanoparticle;
- b. at least one drug chemically immobilized to said biodegradable nanoparticle;
- and
- c. and at least one anti-tumor-receptor antibody chemically immobilized to said biodegradable nanoparticle.
Dependencies are inferred from the claim text.