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US 2006/0149094 A1Published application
Process for generating pivaloylacetate esters via carbonylation of chloropinacolone
OwnerJoseph Zoellerinventor
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Abstract
Pivaloylacetate esters (1) are a useful intermediates for producing chemicals for use in photographic and xerographic reproduction processes. Such esters can be generated by contacting chloropinacolone (2) with CO, an alcohol of formula R1OH, and a base in the presence of a catalyst comprising a source of palladium and certain coordinating trisubstituted phosphines of formula (R3)3P.
Claims12
A process for producing pivaloylacetate esters of formula (1)
- which comprises contacting chloropinacolone (2)
- with carbon monoxide and an alcohol of formula R1OH in the presence of a base and a catalyst comprising palladium and a trisubstituted phosphine wherein R1 is C1-C10 alkyl, C3-C10 cycloalkyl or C6-C10 aryl.
A process for producing pivaloylacetate esters of formula (1)
- which comprises contacting chloropinacolone (2)
- with carbon monoxide and an alcohol represented by R1OH in the presence of a base having formula (R2)3N and a catalyst comprising palladium and a trisubstituted phosphine having formula (R3)3P, wherein R1, R2 and R3 are, independently, C1-C10 alkyl, C3-C10 cycloalkyl or C6-C10 aryl and the contacting is performed at a temperature of about 75° C. to about 175° C. and at a pressure of about 3 to about 50 atm.
A process for producing pivaloylacetate esters of formula (1)
- which comprises contacting chloropinacolone (2)
- with carbon monoxide and an alcohol represented by R1OH in the presence of a base and a catalyst comprising palladium and tricyclohexylphosphine, wherein R1 is methyl or ethyl, the base is triethyl amine, tripropyl amine, tributyl amine, or di-isopropyl ethyl amine, and the contacting is performed at a temperature of about 75° C. to about 175° C. and at a pressure of about 3 to about 50 atm.
Dependencies are inferred from the claim text.