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US 2006/0149078 A1Published application
Olmesartan medoxomil with reduced levels of impurities
AssigneeTeva Pharmaceutical Industries Ltd.
InventorsLilach Hedvati, Gideon Pilarsky
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Abstract
The present invention provides the preparation of olmesartan medoxomil containing less than about 0.1% of one or more of the impurities OLM-Me, OLM-Cl, and OLM-eliminate.
Claims7
A process for preparing olmesartan medoxomil containing less than about 0.1% of one or more of OLM-Me, OLM-Cl, and OLM-eliminate, comprising:
- a) obtaining a sample of trityl olmesartan medoxomil;
- b) measuring the amount of one or more impurities selected from the group consisting of MTT-Me, MTT-Cl, and MTT-eliminate in the sample of trityl olmesartan medoxomil;
- c) selecting a sample of trityl olmesartan medoxomil in which the amount of one or more of the measured impurities is less than about 0.1%;
- and
- d) synthesizing olmesartan medoxomil from the trityl olmesartan medoxomil selected in step c).
2 more elements
Dependencies are inferred from the claim text.