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US 2006/0149057 A1Published application
Method of purifying macrolides
OwnerVilmos Keri, Zoltan Czovekinventors
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Abstract
A method for purifying macrolide is provided in which a loading charge of macrolide is placed in juxtaposition with a bed of wet sorption resin, the loading charge and bed are eluted at a temperature greater than 30° C. with an eluent of an organic solvent selected from the group consisting of THF, acetonitrile, n-propyl alcohol, iso-propyl alcohol, ethyl alcohol, and acetone, the heart cut of the eluent is collected, and purified macrolide is collected.
Claims26
A process for purifying a macrolide, comprising:
- a) providing a loading charge of a macrolide;
- b) loading the loading charge of the macrolide onto a bed of sorption resin;
- c) eluting with an eluent that contains at least one organic solvent selected from the group consisting of:
- THF, acetonitrile, n-propyl alcohol, iso-propyl alcohol, ethyl alcohol, and acetone and water at a temperature greater than about 30° C. to about the boiling temperature of the solvent to obtain an effluent;
- d) collecting the main fraction of the effluent;
- and
- e) recovering the macrolide.
4 more elements
Dependencies are inferred from the claim text.