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US 2006/0149051 A1Published application
Method of preparing an acylimidazolium-type reagent
OwnerThierry Schlama, Franco Manfreinventors
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Abstract
The invention relates to a method of preparing an acylimidazolium-type reagent. More specifically, the invention relates to a salt of N-(benzyloxycarbonyl)-N′-methylimidazolium. The inventive method of preparing an acylimidazolium-type reagent is characterised in that it is obtained by: (i) reacting a reagent comprising a —COX group having formula (II) and an imidazole reagent having formula (III); and (ii) subsequently, adding a strong acid HY to the product thus obtained, said acid having a pKa of less than 1, which produces the desired reagent.
Claims25
1-25. (canceled)
A method of preparing an acylimidazolium-type reagent of formula (I):
- in said formula:
- R1 represents an alkyl or phenyl group,
- R represents an alkyl, alkenyl, cycloalkyl, aryl or arylalkyl group,
- Z represents a valency bond, an oxygen atom or an NR2 group;
- R2 having the same meaning as R,
- Y is an anion originating from an acid whose pKa is less than 1,
- wherein said acylimidazolium-type reagent is obtained by reacting:
- a reagent comprising a group —COX and corresponding to formula (II):
- in said formula:
- R and Z have the meaning given above,
- X represents a bromine or chlorine atom,
- and an imidazole reagent of formula (III):
- in said formula:
- R1 has the meaning given above,
- and then by adding, to the product obtained, a strong acid HY having a pKa of less than 1, which gives the reagent of formula (I), which is recovered.
12 more elements
Dependencies are inferred from the claim text.