Isolation and method of using tissue growth-inducing Frzb
OwnerFrank Luyten, Malcolm Moos +2inventors
InventorsFrank Luyten, Malcolm Moos, Bang Hoang, Shouwen Wang
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Abstract
An isolated cDNA encoding a growth-inducing protein, Frzb, capable of stimulating bone, cartilage, muscle and nerve tissue formation. Frzb binds to and modulates the activity of Wnt growth factors which play a role in various developmental and neoplastic processes. The cDNA and protein sequences of human, bovine and Xenopus Frzb are provided. Production and purification of recombinant Frzb are also described.
Claims4
-18. (canceled)
A method of inducing a cartilage growth in a mammal in need thereof, comprising the step of administering to said mammal at the site of said induction an effective cartilage inducing amount of a pharmaceutical composition comprised of an isolated recombinant Frzb protein having the amino acid sequence shown in SEQ ID NO:
- 2, 4 or 7.
-54. (canceled)
Dependencies are inferred from the claim text.