Canine COX-2 nucleic acid molecules
AssigneeHeska Corporation
InventorsNancy Wisnewski, Kevin Brandt
Life of this patent
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Abstract
The present invention relates to canine COX-1 and COX-2 proteins; to canine COX-1 and COX-2 nucleic acid molecules, including those that encode such COX-1 and COX-2 proteins, respectively; to antibodies raised against such proteins; and to compounds that inhibit the activity of such proteins. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. The present invention also includes therapeutic compositions comprising such inhibitory compounds, particularly those that specifically inhibit COX-2 activity, as well as the use of such therapeutic compositions to treat animals.
Claims17
1-19. (canceled)
A nucleic acid molecule comprising a nucleic acid sequence selected from the group consisting of:
- a. a nucleic acid sequence consisting of SEQ ID NO:1;
- b. a nucleic acid sequence at least 92% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO:4 and SEQ ID NO:7, wherein said nucleic acid sequence encodes a protein having cyclooxygenase activity;
- and
- c. a nucleic acid sequence fully complimentary to the nucleic acid sequence of (a) or (b).
A nucleic acid molecule comprising a nucleic acid sequence selected from the group consisting of:
- a. a nucleic acid sequence encoding the amino acid sequence of SEQ ID NO:2;
- b. a nucleic acid sequence encoding a polypeptide at least 95% identical to the sequence of SEQ ID NO:5, wherein said encoded polypeptide has cyclooxygenase activity;
- and
- c. a nucleic acid sequence fully complementary to the nuclei acid sequence of (a) or (b).
A nucleic acid molecule consisting of a nucleic acid sequence selected from the group consisting of:
- a. a nucleic acid sequence encoding a polypeptide sequence at least 95% identical to SEQ ID NO:2 or SEQ ID NO:5, wherein said encoded polypeptide has cyclooxygenase activity;
- b. a nucleic acid sequence at least 92% identical to SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:7 or SEQ ID NO:8;
- and
- c. a nucleic acid sequence fully complimentary to the nucleic acid sequence of (a) or (b).
Dependencies are inferred from the claim text.