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US 2006/0149038 A1Published application
PRO211 polypeptides
AssigneeGenentech, Inc.
InventorsAudrey Goddard, Austin Gurney, Paul Godowski, William Wood, Napoleone Ferrara
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Abstract
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Claims7
An isolated polypeptide having at least 80% amino acid sequence identity to:
- (a) the amino acid sequence of the polypeptide shown in FIG. 2 (SEQ ID NO:2);
- (b) the amino acid sequence of the polypeptide shown in FIG. 2 (SEQ ID NO:2), lacking its associated signal peptide;
- or,
- (c) the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the cDNA deposited under ATCC accession number 209258;
- wherein said polypeptide inhibits VEGF stimulated proliferation of endothelial cells.
2 more elements
Dependencies are inferred from the claim text.