Cupredoxin derived transport agents and methods of use thereof
AssigneeThe Board of Trustees of the University of Illinois
InventorsAnanda Chakrabarty, Tapas Gupta, Tohru Yamada, Arsenio Fialho
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Abstract
The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains derived from cupredoxins. The invention further discloses methods for treating cancer and diagnosing cancer.
Claims36
A peptide, consisting of a sequence that has at least about 90% amino acid sequence identity to less than a full-length wild-type cupredoxin or H.8 outer membrane protein, and which facilitates the entry of a linked molecule into a mammalian cancer cell.
A peptide which has significant structural homology to the 50-77 amino acid region of Pseudomonas aeruginosa azurin and which facilitates the entry of a linked molecule into a mammalian cancer cell.
A complex comprising a cargo compound and a peptide, wherein the peptide has at least about 90% sequence identity with a cupredoxin, or a fragment thereof, wherein the peptide, or fragment thereof, is linked to the cargo compound, and wherein the peptide facilitates entry of the cargo compound into a mammalian cancer cell.
Dependencies are inferred from the claim text.