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US 2006/0149033 A1Published application
IGF antagonist peptides
AssigneeGenentech, Inc.
InventorsKurt Deshayes, Henry Lowman, Michelle Schaffer, Sachdev Sidhu
Life of this patent
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Abstract
Peptides are provided that antagonize the interaction of IGF-1 with its binding proteins, insulin receptor, and IGF receptor. These IGF antagonist peptides are useful in treating disorders involving IGF-1 as a causative agent, such as, for example, various cancers.
Claims7
A peptide comprising the sequence:
- (Xaa)1(Xaa)2Cys(Xaa)3(Xaa)4Asp(Xaa)5(Xaa)6Gly(Xaa)7(Xaa)8TyrCysTrp(Xaa)9 (SEQ ID NO:5), where (Xaa)1, (Xaa)4, and (Xaa)8 are an amino acid, (Xaa)2 is Arg, Lys, Gly, Ser, or Thr, (Xaa)3 is Ala or Val, (Xaa)5 is Ala or Leu, (Xaa)6 is Ala, Gly, or Leu, (Xaa)7 is Phe, Tyr, Trp, or Gly, and (Xaa)9 is Glu, Asp, Ala, or Gly.
Dependencies are inferred from the claim text.