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US 2006/0148923 A1Published application
Crosslinkable polymeric materials and their applications
AssigneeA Enterprises, Inc.
InventorsArthur Ashman, V. Shastri
Life of this patent
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Abstract
The present invention relates to a novel composition for dental, orthopedic and drug delivery purpose. Specifically, it relates to composition comprising an admixture of a resorbable bone substitute and a crosslinkable prepolymer. It also relates to the composition formed by crosslinking the admixture.
Claims99
A composition comprising a curable admixture of a bone substitute and a crosslinkable prepolymer, wherein the crosslinkable prepolymer comprises an anhydride of
- (i) a monomer or oligomer of a diacid or multifunctional acid and
- (ii) a carboxylic acid molecule which includes a crosslinkable group, wherein the crosslinkable group is an unsaturated hydrocarbon moiety.
A cured composition comprising a bone substitute and a crosslinked prepolymer, wherein the prepolymer prior to crosslinking is one or more anhydride(s) of
- (i) a monomer or oligomer of a diacid or multifunctional acid and
- (ii) a carboxylic acid molecule which includes a crosslinkable group, wherein the crosslinkable group is an unsaturated hydrocarbon moiety.
A method of promoting bone generation comprising the steps of:
- (A) applying to an area in need of such promotion a composition comprising a curable admixture of a bone substitute and a crosslinkable prepolymer, wherein the crosslinkable prepolymer comprises an anhydride of
- (i) a monomer or oligomer of a diacid or multifunctional acid and
- (ii) a carboxylic acid molecule which includes a crosslinkable group, wherein the crosslinkable group is an unsaturated hydrocarbon moiety;
- and
- (B) curing the composition.
2 more elements
A method of stabilizing a dental implant comprising the step of:
- at least partially embedding a dental implant into a cured composition wherein the cured composition is obtained by curing a curable admixture of a bone substitute and a crosslinkable prepolymer, wherein the crosslinkable prepolymer comprises an anhydride of
- (i) a monomer or oligomer of a diacid or multifunctional acid and
- (ii) a carboxylic acid molecule which includes a crosslinkable group, wherein the crosslinkable group is an unsaturated hydrocarbon moiety.
A method of preparing objects of desired shape and size comprising the step of:
- curing in a mold a curable admixture of a bone substitute and a crosslinkable prepolymer, wherein the crosslinkable prepolymer comprises an anhydride of
- (i) a monomer or oligomer of a diacid or multifunctional acid and
- (ii) a carboxylic acid molecule which includes a crosslinkable group, wherein the crosslinkable group is an unsaturated hydrocarbon moiety.
A method of drug delivery comprising the steps of:
- (A) applying to an area in need of drug delivery a composition comprising a curable admixture of a bone substitute and a crosslinkable prepolymer, and a therapeutic agent,
- wherein the crosslinkable prepolymer comprises an anhydride of
- (i) a monomer or oligomer of a diacid or multifunctional acid and
- (ii) a carboxylic acid molecule which includes a crosslinkable group, wherein the crosslinkable group is an unsaturated hydrocarbon moiety;
- and
- (B) curing the composition.
3 more elements
A composition comprising a curable admixture of a polymeric bone substitute and a crosslinkable prepolymer wherein the crosslinkable prepolymer comprises:
- (A) a linear polymer selected from the group consisting of linear, hydrophobic biodegradable polymers and linear non-degradable hydrophilic polymers;
- and
- (B) at least one monomer or macromer containing at least one free radical polymerizable group, wherein at least one of the monomers or macromers includes an anhydride linkage and a polymerizable group selected from the group consisting of acrylate or methacrylate.
A cured composition formed by curing a composition comprising a curable admixture of a polymeric bone substitute and a crosslinkable prepolymer wherein the crosslinkable prepolymer comprises
- (A) a linear polymer selected from the group consisting of linear, hydrophobic biodegradable polymers and linear non-degradable hydrophilic polymers;
- and
- (B) at least one monomer or macromer containing at least one free radical polymerizable group, wherein at least one of the monomers or macromers includes an anhydride linkage and a polymerizable group selected from the group consisting of acrylate or methacrylate.
A method of promoting bone generation comprising the steps of:
- (A) applying to an area in need of such promotion a composition comprising a curable admixture of a polymeric bone substitute and a crosslinkable prepolymer wherein the crosslinkable prepolymer comprises
- (i) a linear polymer selected from the group consisting of linear, hydrophobic biodegradable polymers and linear non-degradable hydrophilic polymers;
- and
- (ii) at least one monomer or macromer containing at least one free radical polymerizable group, wherein at least one of the monomers or macromers includes an anhydride linkage and a polymerizable group selected from the group consisting of acrylate or methacrylate;
- and
- (B) curing the composition.
3 more elements
A method of stabilizing a dental implant comprising the step of:
- at least partially embedding a dental implant into a cured composition wherein the cured composition is obtained by curing a curable admixture of a bone substitute and a crosslinkable prepolymer, wherein the crosslinkable prepolymer comprises
- (i) a linear polymer selected from the group consisting of linear, hydrophobic biodegradable polymers and linear non-degradable hydrophilic polymers;
- and
- (ii) at least one monomer or macromer containing at least one free radical polymerizable group, wherein at least one of the monomers or macromers includes an anhydride linkage and a polymerizable group selected from the group consisting of acrylate or methacrylate.
1 more element
A method of preparing objects of desired shape and size comprising the step of:
- curing in a mold a curable admixture of a bone substitute and a crosslinkable prepolymer, wherein the crosslinkable prepolymer comprises
- (i) a-linear polymer selected from the group consisting of linear, hydrophobic biodegradable polymers and linear non-degradable hydrophilic polymers;
- and
- (ii) at least one monomer or macromer containing at least one free radical polymerizable group, wherein at least one of the monomers or macromers includes an anhydride linkage and a polymerizable group selected from the group consisting of acrylate or methacrylate.
1 more element
A method of drug delivery comprising the steps of:
- (A) applying to an area in need of drug delivery a composition comprising a curable admixture of a bone substitute and a crosslinkable prepolymer, and a therapeutic agent,
- wherein the crosslinkable prepolymer comprises
- (i) a linear polymer selected from the group consisting of linear, hydrophobic biodegradable polymers and linear non-degradable hydrophilic polymers;
- and
- (ii) at least one monomer or macromer containing at least one free radical polymerizable group, wherein at least one of the monomers or macromers includes an anhydride linkage and a polymerizable group selected from the group consisting of acrylate or methacrylate;
- and
- (B) curing the composition.
4 more elements
A composition comprising a curable admixture of a polymeric bone substitute and a crosslinkable prepolymer,
- wherein the crosslinkable prepolymer has at least two polymerizable terminal groups and a viscosity such that, at a temperature of 0° to 60° C., the crosslinkable prepolymer is deformable into a three-dimensional shape and crosslinkable.
The composition of clam 62 wherein the crosslinkable prepolymer contains from 1 to 100 repeating units.
A cured composition formed by curing a composition comprising a curable admixture of a polymeric bone substitute and a crosslinkable prepolymer,
- wherein the crosslinkable prepolymer has at least two polymerizable terminal groups and a viscosity such that, at a temperature of 0° to 60° C., the crosslinkable prepolymer is deformable into a three-dimensional shape and crosslinkable.
A method of promoting bone generation comprising the steps of:
- (A) applying to an area in need of such promotion a composition comprising a curable admixture of a polymeric bone substitute and a crosslinkable prepolymer,
- wherein the crosslinkable prepolymer has at least two polymerizable terminal groups and a viscosity such that, at a temperature of 0° to 60° C., the crosslinkable prepolymer is deformable into a three-dimensional shape and crosslinkable;
- and
- (B) curing the composition.
1 more element
A method of stabilizing a dental implant comprising the step of:
- at least partially embedding a dental implant into a cured composition wherein the cured composition is obtained by curing a curable admixture of a bone substitute and a crosslinkable prepolymer, wherein the crosslinkable prepolymer has at least two polymerizable terminal groups and a viscosity such that, at a temperature of 0° to 60° C., the crosslinkable prepolymer is deformable into a three-dimensional shape and crosslinkable.
A method of preparing objects of desired shape and size comprising the step of:
- curing in a mold a curable admixture of a bone substitute and a crosslinkable prepolymer, wherein the crosslinkable prepolymer has at least two polymerizable terminal groups and a viscosity such that, at a temperature of 0° to 60° C., the crosslinkable prepolymer is deformable into a three-dimensional shape.
A method of drug delivery comprising the steps of:
- (A) applying to an area in need of drug delivery a composition comprising a curable admixture of a bone substitute and a crosslinkable prepolymer, and a therapeutic agent,
- wherein the crosslinkable prepolymer has at least two polymerizable terminal groups and a viscosity such that, at a temperature of 0° to 60° C., the crosslinkable prepolymer is deformable into a three-dimensional shape and crosslinkable;
- and
- (B) curing the composition.
1 more element
A composition comprising a curable admixture of
- (A) a polymeric bone substitute;
- (B) a crosslinkable prepolymer, comprising an anhydride of
- (i) a monomer or oligomer of a diacid or multifunctional acid and
- (ii) a carboxylic acid molecule which includes a crosslinkable group, having an unsaturated hydrocarbon moiety;
- (C) a photoinitiator;
- and
- (D) one or both parts of a redox system containing an oxidizing component and a reducing component.
4 more elements
A method of forming a cured composition comprising:
- (A) forming a curable admixture of
- (i) a polymeric bone substitute;
- (ii) a crosslinkable prepolymer comprising an anhydride of a monomer or oligomer of a diacid or multifunctional acid and a carboxylic acid molecule which includes a crosslinkable group having an unsaturated hydrocarbon moiety;
- (iii) a photoinitiator;
- and
- (iv) a redox system comprising an oxidizing component and a reducing component;
- (B) partially curing said admixture by the reaction of the two component of the redox system;
- and
- (C) exposing the partially cured curable admixture to sufficient radiation to photopolymerize said partially cured curable admixture.
6 more elements
A composition comprising a curable admixture of
- (A) a polymeric bone substitute;
- (B) a crosslinkable prepolymer comprising
- (i) a linear polymer selected from the group consisting of linear, hydrophobic biodegradable polymers and linear non-degradable hydrophilic polymers;
- and
- (ii) at least one monomer or macromer containing at least one free radical polymerizable group, wherein at least one of the monomers or macromers includes an anhydride linkage and a polymerizable group selected from the group consisting of acrylate or methacrylate;
- (C) a photoinitiator;
- and
- (D) one or both parts of a redox system containing an oxidizing component and a reducing component.
5 more elements
A method of forming a cured composition comprising:
- (A) forming a curable admixture of
- (i) a polymeric bone substitute;
- (ii) a crosslinkable prepolymer comprising
- (a) a linear polymer selected from the group consisting of linear, hydrophobic biodegradable polymers and linear non-degradable hydrophilic polymers;
- and
- (b) at least one monomer or macromer containing at least one free radical polymerizable group, wherein at least one of the monomers or macromers includes an anhydride linkage and a polymerizable group selected from the group consisting of acrylate or methacrylate.
- (iii) a photoinitiator;
- and
- (iv) a redox system comprising an oxidizing component and a reducing component;
- (B) partially curing said admixture by the reaction of the two component of the redox system, and
- (C) exposing the partially cured curable admixture to sufficient radiation to photopolymerize said partially cured curable admixture.
8 more elements
A composition comprising a curable admixture of
- (A) a polymeric bone substitute;
- (B) a crosslinkable prepolymer, wherein the crosslinkable prepolymer has at least two polymerizable terminal groups and a viscosity such that, at a temperature of 0° to 60° C., the crosslinkable prepolymer is deformable into a three-dimensional shape and crosslinkable.
- (i) a monomer or oligomer of a diacid or multifunctional acid and
- (ii) a carboxylic acid molecule which includes a crosslinkable group, having an unsaturated hydrocarbon moiety;
- (C) a photoinitiator;
- and
- (D) one or both parts of a redox system containing an oxidizing component and a reducing component.
4 more elements
A method of forming a cured composition comprising:
- (A) forming a curable admixture of
- (i) a polymeric bone substitute;
- (ii) a crosslinkable prepolymer;
- wherein the crosslinkable prepolymer has at least two polymerizable terminal groups and a viscosity such that, at a temperature of 0° to 60° C., the crosslinkable prepolymer is deformable into a three-dimensional shape and crosslinkable.
- (iii) a photoinitiator;
- and
- iv) a redox system comprising an oxidizing component and a reducing component;
- (B) partially curing said admixture by the reaction of the two component of the redox system;
- and
- (C) exposing the partially cured curable admixture to sufficient radiation to photopolymerize said partially cured curable admixture.
7 more elements
Dependencies are inferred from the claim text.