Methods for treatment of beta-amyloid protein-induced ocular disease
OwnerDarrick Kiminventor
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Abstract
The invention provides methods for treating beta-amyloid protein-involved ocular disease including age-related macular degeneration and glaucoma, pharmaceutical compositions and compounds useful for the same, and the use of these compounds for the manufacture of a medicament for treating the same. More particularly, the invention relates to the use of natural product compounds isolated from Curcuma sp., Zingiber sp., Ginkgo biloba, Salvia sp., and Rosmarinus sp. and synthetic chemical analogues thereof, for the treatment of a beta-amyloid protein-involved ocular disease.
Claims11
A method for the treatment of a beta-Amyloid protein-induced ocular disease comprising administering to a subject suffering from a beta-Amyloid protein induced ocular disease a therapeutically effective amount of a composition comprising a member selected from a) a natural or synthetic turmeric compound having anti-βA peptide activity;
- b) a natural or synthetic ginkgo biloba compound having anti-βA peptide activity;
- and c) a natural or synthetic ginger compound having anti-βA peptide activity;
- d) a natural or synthetic sage compound having anti-βA peptide activity;
- and e) a natural or synthetic rosemary compound having anti-βA peptide activity.
The method according to claim 6 wherein:
- R is
- and n is 1-7, and dotted line is optionally a single bond, a double bond (cis or trans), or a triple bond, or having more than one double or triple bond consisting of;
- for example;
- And R is also selected from the group consisting of alkyl, alkenyl, and alkynyl;
- for example;
- and y is 1-9, or having more than one double bond (cis or trans), or triple bond consisting of;
- for example;
- wherein the dotted line configuration is optionally a single bond (cis or trans), or a triple bond, wherein the alkyl, alkenyl, and alkynyl group is selected from ethers and/or thioethers or amines;
- for example;
- wherein z=O, S, NRn, where R=alkyl, alkenyl, alynyl groups;
- and n=1 or 2.
Dependencies are inferred from the claim text.