Ophthalmic compositions and methods of using the same
OwnerKenneth Green, Susan Caballa +1inventors
InventorsKenneth Green, Susan Caballa, George Minno
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Abstract
Ophthalmic compositions are provided that comprise or consist essentially of (a) ketotifen or a ketotifen salt, (b) a non-ionic tonicity agent, and (c) water. The concentration of ketotifen or the ketotifen salt is preferably from 0.01% to 0.05%. The non-ionic tonicity agent is preferably glycerol and the concentration of the glycerol is preferably from 4% to 7%. The compositions preferably have an osmolality of from 400 to 875 milliosmoles/Kg. The compositions may also contain an anti-redness agent. Methods of treating allergic conjunctivitis using the ophthalmic compositions and methods of treating dry eye disease using the ophthalmic compositions are also provided.
Claims48
An ophthalmic composition consisting essentially of:
- (a) ketotifen or a ketotifen salt in a concentration of from 0.01% to 0.05%;
- (b) a non-ionic tonicity agent in a concentration such that the composition has an osmolality of from 400 to 875 milliosmoles/Kg;
- (c) an anti-redness agent;
- and
- (d) water.
An ophthalmic composition consisting essentially of:
- (a) ketotifen or a ketotifen salt in a concentration of from 0.01% to 0.05%;
- (b) glycerol in a concentration of from 3.5% to 7%;
- (c) an anti-redness agent;
- and
- (d) water.
An ophthalmic composition consisting essentially of:
- (a) ketotifen or a ketotifen salt in a concentration of from 0.01% to 0.05%;
- (b) glycerol in a concentration of greater than 3.5% such that the composition has an osmolality of from 400 to 875 milliosmoles/Kg;
- (c) an anti-redness agent;
- and
- (d) water.
An ophthalmic composition comprising:
- (a) ketotifen or a ketotifen salt in a concentration of from 0.01% to 0.05%;
- (b) a non-ionic tonicity agent in a concentration such that the composition has an osmolality of from 400 to 875 milliosmoles/Kg;
- (c) an anti-redness agent;
- and
- (d) water.
An ophthalmic composition comprising:
- (a) ketotifen or a ketotifen salt in a concentration of from 0.01% to 0.05%;
- (b) glycerol in a concentration of from 3.5% to 7%;
- (c) an anti-redness agent;
- and
- (d) water.
An ophthalmic composition comprising:
- (a) ketotifen or a ketotifen salt in a concentration of from 0.01% to 0.05%;
- (b) glycerol in a concentration of greater than 3.5% such that the composition has an osmolality of from 400 to 875 milliosmoles/Kg;
- (c) an anti-redness agent;
- and
- (d) water.
Dependencies are inferred from the claim text.