Chroman derivatives and uses thereof

A compound of formula I:

• or a pharmaceutically acceptable salt thereof,
• wherein:
• m is from 0 to 3;
• p is from 1 to 3;
• q is 0, 1 or 2;
• Ar is optionally substituted aryl or optionally substituted heteroaryl;
• each R1 is independently halo, alkyl, haloalkyl, heteroalkyl, cyano, —S(O)t—Ra, —C(═O)—NRbRc, —SO2—NRbRc, —N(Rd)—C(═O)—Re, —C(═O)N(Rd)—, or —C(═O)—Re, where t is from 0 to 2, Ra, Rb, Rc, Rd and Re each independently is hydrogen or alkyl, and Rf is hydrogen, alkyl, alkoxy or hydroxy;
• R2 is
• n is from 1 to 3;
• R3 and R4 each independently is hydrogen or alkyl;
• R5 and R6 each independently is hydrogen or alkyl, or R5 and R6 together may form ═NRf wherein Rf is hydrogen or alkyl;
• and
• R7 and R8 each independently is hydrogen or alkyl, or one of R7 and R8 is hydrogen and the other is an optionally substituted 5- or six membered heteroaryl or heterocyclyl containing one or two nitrogens, or R7 and R8 together with the nitrogen to which they are attached may form an amidinyl group, a urea group, a guanidinyl group, or a five- or six-membered heterocyclic ring that optionally includes an additional heteroatom selected from O, N and S and which is optionally substituted with amino, or one of R7 and R8 and one of R5 and R6 together with the atoms to which they are attached may form a five- or six-membered heterocyclic ring that optionally includes an additional heteroatom selected from O, N and S.