Chemical compounds
OwnerDavid Deaton, Barry Shearer +1inventors
InventorsDavid Deaton, Barry Shearer, David Uehling
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Abstract
The present invention discloses compounds of Formula I. The present invention also discloses beta-3 agonists of formula I and methods for treating beta-3 mediated diseases and condition using the compounds of formula I, in particular methods for treating diabetes or obesity.
Claims7
A method for the prevention or treatment of clinical conditions or diseases susceptible to amelioration by administration of an atypical beta-adrenoceptor agonist, comprising administration of an effective amount of a compound of formula (I), or a pharmaceutically acceptable derivative thereof:
- wherein X is oxygen or sulfur, and where the heterocycle containing X is substituted meta or para to the depicted NH;
- R1 is hydrogen or C1-6alkyl;
- R represents substituents selected from C1-6 alkyl, halogen, trifluoromethyl, and
- C1-6alkoxy;
- and
- n represents an integer from 0-4.
A method for the prevention or treatment of obesity comprising administration of an effective amount of a compound selected from:
- 2-(3-{2R-[2-(3-Chlorophenyl)-2R-hydroxyl-ethylamino]propylamino}phenyl)furan-3-carboxylic acid;
- 2-(3-{[2-(3-Chlorophenyl)-2R-hydroxyl-ethylamino]ethylamino}phenyl)furan-3-carboxylic acid;
- 2-(4-{2R-[2-(3-Chlorophenyl)-2R-hydroxylethylamino]propylamino}phenyl)furan-3-carboxylic acid;
- 2-(3-{2R-[2-(3-Chlorophenyl)-2R-hydroxyl-ethylamino]propylamino}phenyl)thiophene-3-carboxylic acid;
- 2-(3-{[2-(3-Chlorophenyl)-2R-hydroxyl-ethylamino]ethylamino)phenyl)thiophene-3-carboxylic acid;
- 2-(4-{2R-[2-(3-Chlorophenyl)-2R-hydroxyl-ethylamino]propylamino}phenyl)thiophene-3-carboxylic acid;
- or pharmaceutically acceptable derivatives thereof.
A method for the prevention or treatment of urinary incontinence comprising administration of an effective amount of a compound selected from:
- 2-(3-{2R-[2-(3-Chlorophenyl)-2R-hydroxyl-ethylamino]propylamino}phenyl)furan-3-carboxylic acid;
- 2-(3-{[2-(3-Chlorophenyl)-2R-hydroxyl-ethylamino]ethylamino}phenyl)furan-3-carboxylic acid;
- 2-(4-{2R-[2-(3-Chlorophenyl)-2R-hydroxylethylamino]propylamino}phenyl)furan-3-carboxylic acid;
- 2-(3-{2R-[2-(3-Chlorophenyl)-2R-hydroxyl-ethylamino]propylamino}phenyl)thiophene-3-carboxylic acid;
- 2-(3-{[2-(3-Chlorophenyl)-2R-hydroxyl-ethylamino]ethylamino}phenyl)thiophene-3-carboxylic acid;
- 2-(4-{2R-[2-(3-Chlorophenyl)-2R-hydroxyl-ethylamino]propylamino}phenyl)thiophene-3-carboxylic acid;
- or pharmaceutically acceptable derivatives thereof.
Dependencies are inferred from the claim text.