Pharmaceutical formulations of celcoxib
AssigneeTransform Pharmaceuticals, Inc.
InventorsSteven Bernstein, Hongming Chen, Colin Gardner, Meegan LeMott, Szu-Wen Wang
Life of this patent
Estimating the term…
Abstract
Liquid formulations of celecoxib have been found to provide faster pain relief than conventional solid formulations of celecoxib. The present invention provides combinations of excipients in which celecoxib is highly soluble for formulation as pharmaceutical compositions.
Claims13
A pharmaceutical composition comprising celecoxib;
- a first excipient which is a propylene glycol fatty acid monoester;
- a second excipient selected from the group consisting of a polyethylene glycol, a polyoxyl castor oil, and a polysorbate;
- and a third excipient selected from the group consisting of a propylene glycol fatty acid monoester, a polysorbate, a sorbitan fatty acid monoester, a poloxamer, a polyethylene glycol, a polyethylene glycol fatty acid monoester, and a polyoxyl castor oil.
2-82. (canceled)
A pharmaceutical composition comprising celecoxib;
- a first excipient which is a poloxamer;
- a second excipient selected from the group consisting of a propylene glycol fatty acid monoester, a polyoxamer, and a plant oil;
- and a third excipient selected from the group consisting of a propylene glycol fatty acid monoester, a poloxamer, a polysorbate and a sorbitan fatty acid monoester.
A pharmaceutical composition comprising celecoxib;
- a first excipient which is a polyethylene glycol;
- a second excipient selected from the group consisting of a polyethylene glycol, a polyoxyl castor oil and a sorbitan fatty acid monoester;
- and a third excipient selected from the group consisting of a polyethylene glycol, a sorbitan fatty acid monoester and a propylene glycol fatty acid monoester.
A pharmaceutical composition comprising celecoxib;
- a first excipient which is a sorbitan fatty acid monoester;
- a second excipient selected from the group consisting of a polyethylene glycol and a polysorbate;
- and a third excipient selected from the group consisting of a propylene glycol fatty acid monoester, a polyoxamer, a polyethylene glycol, a polyoxyl castor oil, a polysorbate, a plant oil or a sorbitan fatty acid monoester.
A pharmaceutical composition comprising celecoxib;
- a first excipient which is a polyoxyl castor oil;
- a second excipient selected from the group consisting of a propylene glycol fatty acid monoester, a poloxamer, a polyethylene glycol, a polyoxyl castor oil, a polysorbate and a sorbitan fatty acid monoester;
- and a third excipient selected from the group consisting of a propylene glycol fatty acid monoester, a polyoxamer, a polyethylene glycol, a polyoxyl castor oil, a polysorbate, a plant oil and a sorbitan fatty acid monoester.
A pharmaceutical composition comprising celecoxib;
- a first excipient which is a polysorbate;
- a second excipient selected from the group consisting of a propylene glycol fatty acid monoester, a poloxamer, a polyethylene glycol, a polyoxyl castor oil, a polysorbate and a sorbitan fatty acid monoester;
- and a third excipient selected from the group consisting of a propylene glycol fatty acid monoester, a polyethylene glycol, a polyoxyl castor oil, a polysorbate a plant oil, a sorbitan fatty acid monoester and a poloxamer.
Dependencies are inferred from the claim text.