Compounds for use in the treatment of aids and other viral diseases and HIV-related infections and compositions containing such compounds, methods of treating such diseases and infections and methods of making such compounds and compositions

A method of inducing AICD, comprising administering a composition comprising a compound of formula I:

• wherein:
• the dotted line represents a single or a double bond;
• R1 and R2 are the same or different and independently of each other represent —CH2OH, —CH2OR4, —CH(OH)CH3, —CH(OR4)CH3 or a group represented by the formula:
• wherein:
• R4 is a linear or branched C1-C4 alkyl;
• R5 is H, OH or OR6 where R6 is a linear or branched C1-C4 alkyl;
• A-B is a group represented by the formula:
• Z is —CH2CH2O, —CH(CH3)CH2O or —CH2CH(CH3)O;
• and
• m is an integer of 0 or 1, n is an integer of 1-500 and X is O, —CH2O, —CH2CH2O, —CH(CH3)CH2O or —CH2CH(CH3)O, or
• m is 1, n is an integer of 0 to 500 and X is —CH2O, —CH2CH2O, —CH(CH3)CH2O or —CH2CH(CH3)O;
• or a salt or hydrate thereof;
• in a carrier which minimizes micellar formation or van der Waals attraction of molecules of said compound.

A method of inhibiting a chemokine receptor, comprising administering to a subject in need thereof a compound of formula I:

• wherein:
• the dotted line represents a single or a double bond;
• R1 and R2 are the same or different and independently of each other represent —CH2OH, —CH2OR4, —CH(OH)CH3, —CH(OR4)CH3 or a group represented by the formula:
• wherein:
• R4 is a linear or branched C1-C4 alkyl;
• R5 is H, OH or OR6 where R6 is a linear or branched C1-C4 alkyl;
• A-B is a group represented by the formula:
• Z is —CH2CH2O, —CH(CH3)CH2O or —CH2CH(CH3)O;
• and
• m is an integer of 0 or 1, n is an integer of 1-500 and X is O, —CH2O, —CH2CH2O, —CH(CH3)CH2O or —CH2CH(CH3)O, or
• m is 1, n is an integer of 0 to 500 and X is —CH2O, —CH2CH2O, —CH(CH3)CH2O or —CH2CH(CH3)O;
• or a salt or hydrate thereof.

A method of modulating malignant metastasis, comprising administering to a subject in need thereof a compound of formula I:

• wherein:
• the dotted line represents a single or a double bond;
• R1 and R2 are the same or different and independently of each other represent —CH2OH, —CH2OR4, —CH(OH)CH3, —CH(OR4)CH3 or a group represented by the formula:
• wherein:
• R4 is a linear or branched C1-C4 alkyl;
• R5 is H, OH or OR6 where R6 is a linear or branched C1-C4 alkyl;
• A-B is a group represented by the formula:
• Z is —CH2CH2O, —CH(CH3)CH2O or —CH2CH(CH3)O;
• and
• m is an integer of 0 or 1, n is an integer of 1-500 and X is O, —CH2O, —CH2CH2O, —CH(CH3)CH2O or —CH2CH(CH3)O, or
• m is 1, n is an integer of 0 to 500 and X is —CH2O, —CH2CH2O, —CH(CH3)CH2O or —CH2CH(CH3)O;
• or a salt or hydrate thereof.

A method of inhibiting fibrosis or aberrant fibroblast proliferation, comprising administering to a subject in need thereof a compound of formula I:

• wherein:
• the dotted line represents a single or a double bond;
• R1 and R2 are the same or different and independently of each other represent —CH2OH, —CH2OR4, —CH(OH)CH3, —CH(OR4)CH3 or a group represented by the formula:
• wherein:
• R4 is a linear or branched C1-C4 alkyl;
• R5 is H, OH or OR6 where R6 is a linear or branched C1-C4 alkyl;
• A-B is a group represented by the formula:
• Z is —CH2CH2O, —CH(CH3)CH2O or —CH2CH(CH3)O;
• and
• m is an integer of 0 or 1, n is an integer of 1-500 and X is O, —CH2O, —CH2CH2O, —CH(CH3)CH2O or —CH2CH(CH3)O, or
• m is 1, n is an integer of 0 to 500 and X is —CH2O, —CH2CH2O, —CH(CH3)CH2O or —CH2CH(CH3)O;
• or a salt or hydrate thereof