Novel compounds that modulate PPARy type receptors and cosmetic/pharmaceutical compositions comprised thereof

A compound having the following structural formula (I):

• in which:
• R1 is a radical of formula (a) or (b) below:
• R3 and R4 are as defined below;
• R2 is an alkyl radical having from 1 to 12 carbon atoms, an aryl radical, an aralkyl radical, a heteroaryl radical, a heterocyclic radical, a 9-fluorenylmethyl radical or a radical of formula (CH2)m(NR5)n(C(O,N))pR6;
• R5, R6, m, n and p are as defined below;
• R3 is a radical selected from among the following formulae:
• R7, R8, V, W and Y are as defined below;
• R4 is an alkyl radical having from 1 to 12 carbon atoms, a radical OR9 or a radical SR9 or NHR9;
• R5 and R7, which may be identical or different, are each a hydrogen atom, an alkyl radical having from 1 to 12 carbon atoms, an aryl radical, an aralkyl radical, a heteroaryl radical or a heterocyclic radical, with the proviso that when Y is an nitrogen atom, then formula (e) is not substituted by a radical R7;
• R6 and R8, which may be identical or different, are each:
• a radical O—(CH2)v—R10,
• a hydroxyl radical, an alkyl radical having from 1 to 12 carbon atoms, an aryl radical, an aralkyl radical, a heteroaryl radical, a heterocyclic radical,
• a radical
• or a radical NR′(CH2)vR10;
• R10, R′, R″ and v are as defined below;
• R9 is an alkyl radical having from 1 to 12 carbon atoms, or a radical selected from among those of the following formulae:
• (h) α-amino acid N-protected with standard amine-protecting groups;
• R11, Q and p are as defined below;
• m has the values 0, 1 or 2;
• n and p have the values 0 or 1;
• Q is an oxygen or sulfur atom or NR5;
• V is an oxygen, a nitrogen or sulfur atom;
• W is a nitrogen atom or a radical C—R5;
• Y is a nitrogen atom or a carbon atom;
• Z is an oxygen, nitrogen or sulfur atom;
• v has the values 1, 2 or 3;
• R10 is an alkyl radical having from 1 to 12 carbon atoms, an aryl, aralkyl, heteroaryl or heterocyclic radical, a radical NH—CO—R12, a radical NH—CO—O—R12 or C—R12R13 or a radical N—R12R13, wherein R12 and R13 are as defined below;
• R′ is a hydrogen atom, an alkyl radical having from 1 to 12 carbon atoms, a heteroaryl radical or a heterocyclic radical;
• R″ is a hydrogen atom, an alkyl radical having from 1 to 12 carbon atoms, an aryl radical, an aralkyl radical, optionally substituted with one or more halogens, a heteroaryl radical, a heterocyclic radical, a radical (CH2)v—R10, or a radical NHR10 or NR10R10;
• R11 is a hydrogen atom, an alkyl radical having from 1 to 12 carbon atoms, an aryl radical, an aralkyl radical, a heteroaryl radical, a heterocyclic radical or a radical (CO)s(Z)tR10 with s and t having the values 0, 1 or 2;
• R12 is a hydrogen atom, an alkyl radical having from 1 to 12 carbon atoms, an aryl radical, an aralkyl radical, a heteroaryl radical or a heterocyclic radical;
• R13 is a hydrogen atom or an alkyl radical having from 1 to 12 carbon atoms;
• X is a radical having the following structure:
• —(CH2)z—NR14—C(T)-(D)w-
• wherein D, z, T and R14 are as defined below;
• T is an oxygen or sulfur atom;
• D is an oxygen or sulfur atom, a radical —NR15 or a radical CH2, wherein R15 is as defined below;
• z has the values 0 or 1;
• w has the values from 0 to 6;
• and
• R14 and R15 are each a hydrogen atom or an alkyl radical having from 1 to 12 carbon atoms,
• Ar1 and Ar2, which may be identical or different, are each an optionally substituted aromatic radical of one of the formulae:
• wherein A is an S or O atom or a radical N—R13, with the proviso that, when Ar1 or Ar2 is a phenyl radical, then Ar2 or Ar1 is necessarily a heteroaryl radical,
• and the optical and geometrical isomers and also the salts thereof.