Carboxamide derivatives

A compound of formula (I),

• or a pharmaceutically acceptable salt or solvate thereof, wherein,
• P is aryl, heteroaryl, heterocyclyl or cycloalkyl;
• W, X and Y form a 5-membered nitrogen containing heteroaromatic ring wherein W, X and Y may be selected from CR1a, NR1b, N, S and O;
• R1a and R1b independently are —H, alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, aryloxyalkyl,- (CH2)xOR4 or —(CH2)x NR4R5;
• R2 is —H, alkyl, alkoxy or halo;
• R2a is alkyl, alkoxy, halo or CF3;
• R2b is alkyl, alkoxy, halo or CF3;
• R3 is —H, halo, alkyl, alkoxy, cycloalkyl, or aryl wherein said aryl group may be optionally substituted by one or more groups R2a;
• heteroaryl wherein said heteroaryl group may be optionally substituted by one or more groups R2b;
• aralkyl, aralkoxy, cycloalkylalkyl, cycloalkylalkoxy, —CN, —NO2, —OH, —OCF3, —CF3, —NR4R5—S(O)mR6, —S(O)2NR4R5, —OS(O)2R6, —OS(O)2CF3, —O(CH2)xNR4R5, —O(CH2)xOR4—C(O)CF3, —C(O)alkyl, —C(O)cycloalkyl, —C(O)aralkyl, —C(O)Ar, —C(O)(CH2)xOR6, —C(O)(CH2)xNR4R5, —C(O)alkoxy, —C(O)NR4R5, —(CH2)xC(O)alkoxy, —(CH2)xOC(O)R6, —(CH2)xOR6, —(CH2)xNR4R5, —(CH2)xC(O)NR4R5, —(CH2)xN(R4)C(O)R6, —(CH2)xS(O)2NR4R5, —(CH2)xN(R4)S(O)2R6, -ZAr, —(CH2)xS(O)2R6, —(OCH2)xS(O)2R6, —O(CH2)xS(O)2R6, —N(R4)S(O)2R6, —N(R4)C(O)R6 or —(CH2)xC(O)alkyl;
• R4 and R5 may be the same or different and represent —H or alkyl or R4 and R5 together with the nitrogen atom to which they are attached form a heterocyclic ring;
• R6 is —H, alkyl or aryl;
• R7 is —H, alkyl or aryl;
• Ar is aryl or heteroaryl;
• m is 0, 1 or 2;
• r is 0, 1, 2 or 3;
• s is 0, 1, 2, 3, 4, 5 or 6;
• x is 0, 1, 2, 3, 4, 5 or 6;
• and
• Z is a bond, O, S, NR7 or CH2.