Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors

An 8-aza-bicyclo[3.2.1]octane derivative of the Formula I:

• or any of its isomers or any mixture of its isomers, or a pharmaceutically acceptable salt thereof,
• wherein
• R represents hydrogen or alkyl;
• R2 represents —CH2—X—Ra;
• wherein X represents —O— or —S—;
• Ra represents
• wherein Rb and Rc are independently selected from the group consisting of:
• halo, hydroxy, amino, cyano, nitro, trifluoromethyl, trifluoromethoxy, alkoxy, cycloalkoxy, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, and alkynyl;
• or Ra represents naphthyl;
• which naphthyl is optionally with substituted with one or more substituents selected from the group consisting of:
• halo, hydroxy, amino, cyano, nitro, trifluoromethyl, trifluoromethoxy, alkoxy, cycloalkoxy, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, and alkynyl
• R3 represents phenyl or naphthyl;
• which phenyl or naphthyl is optionally substituted with one or more substituents selected from the group consisting of:
• halo, hydroxy, amino, cyano, nitro, trifluoromethyl, trifluoromethoxy, alkoxy, cycloalkoxy, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, and alkynyl;
• or R3 represents hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, or alkynyl;
• which alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, or alkynyl is optionally substituted with one or more substituents from the group consisting of:
• halo, hydroxy, amino, cyano, nitro, trifluoromethyl, trifluoromethoxy, alkoxy, cycloalkoxy, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, and alkynyl.