Novel coumarin-amide derivatives and its preparation, said drug composition and its use

A compound represented by the following general formula (I)

• characterized in that R3 is selected from the group consisting of H, carboxyl, alkyloxycarbonyl, 5′-(phenyloxadiazol-2′-yl), 5′-(pyridyl-4″-oxadizol-2′-yl),
• CONHR9, wherein R9 is selected from the group consisting of C2-C8 fatty acid, benzoxamido, isonicotinamido, un-substituted or mono- or multi-substituted phenyl wherein the substituent may be hydroxyl, C1-C8 alkoxyl, CF3, carboxyl, alkyloxycarbonyl, OCH2CO2H, NO2, halogen, SO3H, SO2NHR11, wherein R11 is selected from the group consisting of hydrogen, amidino, 2″-thiazolyl, 3″-(5″-methylisooxazolyl), 2″-pyrimidinyl, 2″-(4″,6″-dimethylpyrimidinyl), 4″-(5″,6″-dimethoxypyrimidinyl);
• R4 is selected from the group consisting of hydrogen, CONHR10, wherein R10 is selected from the group consisting of C2-C8 fatty acid, benzoxamido, isonicotiniamido, un-substituted, mono- or multi-substituted phenyl wherein the substituent may be hydroxyl, C1-C8 alkoxyl, CF3, carboxyl, alkoxycarbonyl, OCH2CO2H, NO2, halogen, SO3H, SO2NHR12, wherein R12 is selected from the group consisting of H, amidino, 2″-thiazolyl, 3″-(5″-methylisooxazolyl), 2″-pyrimidinyl, 2″-(4″,6″-dimethyl-pyrimidinyl), 4″-(5″,6″-dimethoxy pyrimidinyl);
• R5 is selected from the group consisting of H, C1-C4 alkyl;
• R6 is selected from the group consisting of H, C1-C12 alkyl, halogen, NO2, CONHR13, wherein R13 is substituted phenyl;
• R7 is selected from the group consisting of H, hydroxyl, C1-C4 alkyl or alkoxyl, carboxylalkylenoxyl, OCH2CONHR14, wherein R14 is selected from the group consisting of un-substituted, mono- or multi-substituted phenyl wherein the substituent may be hydroxyl, OCH3, CF3, CO2H, CO2C2H5, NO2;
• R8 is selected from the group consisting of H, C1-C4 alkyl or alkoxyl, NO2;
• provided that, in case that R3, R5 and R5 are H and R7 is OH, R4 and R7 are not groups selected from H, C1-6 alkyl or C1-6 alkoxy.