1-(aminoalkyl)-3-sulfonylazaindoles as 5-hydroxytryptamine-6 ligands

A method for the treatment of a disorder of the central nervous system related to or affected by the 5-HT6 receptor in a patient in need thereof which comprises providing to said patient a therapeutically effective amount of a compound of formula I

• wherein
• W is N or CR7;
• X is N or CR8;
• Y is N or CR9;
• Z is N or CR10 with the proviso that at least one and no more than two of W, X, Y and Z must be N;
• n is an integer of 2, 3, 4 or 5;
• R1 is an optionally substituted C1-C6alkyl, C3-C7cycloalkyl, aryl, or heteroaryl group or an optionally substituted 8- to 13-membered bicyclic or tricyclic ring system having a N atom at the bridgehead and optionally containing 1, 2 or 3 additional heteroatoms selected from N, O or S;
• R2 is H, halogen, or a C1-C6alkyl, C1-C6alkoxy, C3-C7cycloalkyl, aryl or heteroaryl group each optionally substituted;
• R3 and R4 are each independently H or an optionally substituted C1-C6alkyl group;
• R5 and R6 are each independently H or a C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C7cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted , or R5 and R6 may be taken together with the atom to which they are attached to form an optionally substituted 5- to 8-membered ring optionally containing an additional heteroatom selected from O, NR11 or SOm;
• R7, R8, R9 and R10 are independently H, halogen, CN, OCO2R12, CO2R13, CONR14R15, SOpR16, NR17R18, OR19, COR20, or a C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C7cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted;
• R1, R12, R13, R16, R19 and R20 are each independently H or a C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C6cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted;
• R14 and R15 are each independently H or an optionally substituted C1-C6alkyl group or R14 and R15 may be taken together with the atom to which they are attached to form a 5- to 7-membered ring optionally containing another heteroatom selected from O, NR22 or S;
• R17 and R18 are each independently H or an optionally substituted C1-C4alkyl group or R17 and R18 may be taken together with the atom to which they are attached to form a 5- to 7-membered ring optionally containing another heteroatom selected from O, NR21 or SOx;
• R21 and R22 are each independently H or a C1-C6alkyl, C2-C6alkenyl, C3-C7cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted;
• and
• m, p and x are each independently 0 or an integer of 1 or 2;
• or the stereoisomers thereof or the pharmaceutically acceptable salts thereof.