Phosphodiesesterase 4 inhibitors for the treatment of a cognitive deficit
AssigneeCold Spring Harbor Laboratory
InventorsTimothy Tully, Filippo Cavalieri, Rusiko Bourtchouladze
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Abstract
The present invention provides methods of treating cognitive deficits associated with mental retardation. The methods comprise combining cognitive training protocols and a general administration of phosphodiesterase 4 inhibitors.
Claims19
Use of a phosphodiesterase 4 inhibitor for the manufacture of a medicament for use in treatment of a cognitive deficit associated with mental retardation, wherein said treatment comprises:
- a) administering to an animal in need of said treatment the phosphodiesterase 4 inhibitor;
- and
- b) training said animal under conditions sufficient to produce an improvement in performance by said animal of a cognitive task whose deficit is associated with mental retardation,
- whereby said cognitive deficit is treated.
Use of a phosphodiesterase 4 inhibitor for the manufacture of a medicament for use in treatment of a cognitive deficit associated with Rubinstein-Taybi syndrome, wherein said treatment comprises:
- a) administering to an animal in need of said treatment said phosphodiesterase 4 inhibitor;
- and
- b) training said animal under conditions sufficient to produce an improvement in performance by said animal of a cognitive task whose deficit is associated with Rubinstein-Taybi syndrome,
- whereby said cognitive deficit is treated.
Dependencies are inferred from the claim text.