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US 2006/0148811 A1Published application
Aralkyl-ketone piperazine derivatives and their uses as new antalgic or ataractic agent
AssigneeShanghai Institute of Pharmaceutical Industry
InventorsJianqi Li, Liying Huang, Chunnian Zhang, Xican Tang, Guoyuan Hu
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Abstract
Arylalkyl ketone piperazine derivatives of the formula: and pharmaceutical compositions comprising the same. Also dislcosed are methods for using the compounds as analgesic and sedative agents. The compounds of the present invention have good analgesic and sedative activities but few side effects.
Claims12
1-8. (canceled)
A compound of formula I:
- wherein
- Ar1 and Ar2 independently represent:
- each of R1, R2 and R3 represents any one of hydrogen, a C1-C3 alkyl group, a C5 or C6 cycloalkyl group, phenyl, substituted phenyl, hydroxyl, methoxy, ethoxy, amino, substituted amino, halogen, carboxylic acid, carboxylic ester, nitryl or acetonitrile group;
- Y represents one of C, N, or O;
- Z represents a five or six-membered ring containing one of C, S, N or O;
- and
- n and m represent independently 0, 1, 2, or 3.
4 more elements
Dependencies are inferred from the claim text.