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US 2006/0148807 A1Published application
Pyrrolo[1,2b]pyridazine compounds and their uses
AssigneePfizer Inc.
InventorJian-min Fu
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Abstract
Disclosed are novel CRF receptor antagonists and their use as treatment of a variety of disorders, including disorders manifesting hypersecretion of CRF or associated with CRF or CRF receptors, such as anxiety, and depression. CRF receptor antagonists of the invention have the structure of formula (I): including stereoisomers or mixture of stereoisomers, pharmaceutically acceptable prodrugs, or pharmaceutically acceptable salts thereof, wherein in formula (I) R is H or Me.
Claims24
A method for screening for ligands for CRF receptors, which method comprises:
- a) carrying out a competitive binding assay with a CRF receptor, a compound of Formula (I)
- or a stereoisomeric form thereof, or a mixture of stereoisomeric forms thereof, a pharmaceutically acceptable prodrug thereof, or a pharmaceutically acceptable salt thereof, wherein in formula (I) R is H or Me including or, which is labeled with a detectable label, and a candidate ligand;
- and b) determining the ability of said candidate ligand to displace said labeled compound.
Dependencies are inferred from the claim text.