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US 2006/0148801 A1Published application
Anti-tumor compounds
AssigneeNational Health Research Institutes
InventorsHsing-Pang Hsieh, Yu-Sheng Chao, Jing-Ping Liou, Jang-Yang Chang, Yen-Shih Tung
Life of this patent
Estimating the term…
Abstract
Compounds of the following formula: wherein A, D, Q, T, U, V, W, X, Y, Z, R1, and ---- are as defined herein. This invention also relates to a method of inhibiting tubulin polymerization, or treating cancer or an angiogenesis-related disorder with one of these compounds.
Claims30
A compound of the following formula:
- in which
- each ---- is a single bond or a double bond;
- A is C(═O), CRR′, O, NR, S, SO, or SO2;
- D is aryl or hetereoaryl;
- R1 is selected from H, alkyl, aryl, alkoxy, hydroxy, halo, amino, or alkylamino;
- each of Q, U, V, and Y, independently, is CR or N;
- X is N, CR, or NR′;
- Z is C;
- and
- each of T and W is C or N, at least one of T and W being C;
- provided that
- when T is C and W is N, the bond between T and W is a single bond, the bond between T and Z is a double bond, the bond between Y and Z is a single band, the bond between X and Y is a double bond, the bond between W and X is a single bond, and X is N or CR;
- when T is N and W is C, the bond between T and W is a single bond, the bond between T and Z is a single bond, the bond between Y and Z is a double band, the bond between X and Y is a single bond, the bond between W and X is a double bond, and X is N or CR;
- and
- when T is C and W is C, the bond between T and W is a double bond, the bond between T and Z is a single bond, the bond between Y and Z is a double band, the bond between X and Y is a single bond, the bond between W and X is a single bond and X is NR and Y is N, or X is NR, Y is CR, and at least one of Q, U and V is N;
- wherein each of R and R′, independently, is H, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cyclyl, heterocyclyl, SO3Ra, SO2Ra, SO2NRaRb, CORa, COORa, or CONRaRb;
- each Ra and Rb, independently, is H, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cyclyl, or heterocyclyl.
14 more elements
A compound of the following formula:
- in which
- each ---- is a single bond or a double bond;
- A is C(═O), CRR′, O, NR, S, SO, or SO2;
- D is aryl or hetereoaryl;
- R1 is selected from alkyl, aryl, alkoxy, hydroxy, halo, amino, or alkylamino;
- each of Q, U, or V, independently, is CR or N;
- X is O or S;
- Y is CR″ or N;
- each of T, W, and Z is C;
- the bond between T and W is a double bond;
- the bond between T and Z is a single bond;
- the bond between Y and Z is a double band;
- the bond between X and Y is a single bond;
- and
- the bond between W and X is a single bond;
- wherein each of R and R′, independently, is H, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cyclyl, heterocyclyl, SO3Ra, SO2Ra, SO2NRaRb, CORa, COORa, or CONRaRb, and R″ is H, alkyl, alkenyl, alkynyl, heteroaryl, cyclyl, heterocyclyl, SO3Ra, SO2Ra, SO2NRaRb, CORa, COORa, or CONRaRb;
- each Ra and Rb, independently, is H, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cyclyl, or heterocyclyl.
14 more elements
Dependencies are inferred from the claim text.