Novel tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them

A compound of formula (IIIe)

• its tautomeric forms, its stereoisomers, or, its pharmaceutically acceptable salts, wherein R1, R2, R3, and R4 are the same or different and represent hydrogen, halogen, hydroxy, cyano, nitro, formyl, or optionally substituted groups selected from alkyl, cyclo(C3-C6)alkyl alkoxy, cycloalkoxy, aryl, aryloxy, aralkyl, aralkoxy, heterocyclyl selected from the group consisting of aziridinyl, pyrrolidinyl, morpholinyl, piperidinyl and piperazinyl heteroaryl selected from the group consisting of pyridyl, thienyl, furyl, pyrrolyl, oxazolyl, thiazolyl, imidazolyl, oxadiazolyl, tetrazolyl, benzopyranyl and benzofuranyl;
• heteroaralkyl, heteroaryloxy, heteroaralkoxy, acyl, acyloxy, hydroxyalkyl, amino, acylamino, arylamino, aralkylamino, aminoalkyl, alkoxycarbonyl, aryloxycarbonyl, aralkyloxycarbonyl, alkylamino, alkoxyalkyl, aryloxyalkyl, aralkoxyalkyl, alkylthio, thioalkyl, aralkoxycarbonylamino, alkoxycarbonylamino, aryloxycarbonylamino, COOH, CONH2, CONHMe, CONMe2, CONHEt, CONHPh, SO2OH, SO2NH2, SO2NHMe, SO2NMe2, or SO2NHCF3, wherein when R1, R2, R3 or R4 is substituted, the substituent is selected from halogen, hydroxy, nitro, alkyl, cyclo(C3-C6)alkyl, alkoxy, cycloalkoxy, aryl, aralkyl, aralkoxyalkyl, heterocyclyl selected from the group consisting of aziridinyl, pyrrolidinyl, morpholinyl, piperidinyl and piperazinyl;
• heteroaryl selected from the group consisting of pyridyl, thienyl, furyl, pyrrolyl, oxazolyl, thiazolyl, imidazolyl, oxadiazolyl, tetrazolyl, benzopyranyl and benzofuranyl;
• heteroaralkyl, acyl, acyloxy, hydroxyalkyl, amino, acylamino, arylamino, aminoalkyl, aryloxy, alkoxycarbonyl, alkylamino, alkoxyalky, alkylthio, thioalkyl groups, COOH, CONH2, CONHMe, CONMe2, CONHEt, or CONHPh, or SO2OH, or SO2NH2, SO2NHMe, SO2NMe2, or SO2NHCF3;
• A is an optionally substituted benzene ring wherein when A is substituted, the substituent is selected from halogen, hydroxy, nitro, alkyl, cyclo(C3-C6)alkyl, alkoxy, cycloalkoxy, aryl, aralkyl, aralkoxyalkyl, heterocyclyl selected from the group consisting of aziridinyl, pyrrolidinyl, morpholinyl, piperidinyl and piperazinyl;
• heteroaryl selected from the group consisting of pyridyl, thienyl, furyl, pyrrolyl, oxazolyl, thiazolyl, imidazolyl, oxadiazolyl, tetrazolyl, benzopyranyl and benzofuranyl;
• heteroaralkyl, acyl, acyloxy, hydroxyalkyl, amino, acylamino, arylamino, aminoalkyl, aryloxy, alkoxycarbonyl, alkylamino, alkoxyalky, alkylthio, thioalkyl groups, COOH, CONH2, CONHMe, CONMe2, CONHEt, CONHPh, SO2OH, SO2NH2, SO2NHMe, SO2NMe2, or SO2NHCF3;
• X represents oxygen, n is an integer of 1 or 2 and L1 is methane sulphonate, or trifluoromethane sulphonate.