Novel diazabicyclic aryl derivatives

A diazabicyclic aryl derivative represented by Formula I

• any of its enantiomers or any mixture of its enantiomers, or a prodrug, or a pharmaceutically-acceptable addition salt thereof, wherein
• n is 1, 2 or 3;
• and
• X and Y, independently of one another, represents CR2, CR3 and/or N, wherein R2 and R3, independently of one another, represent hydrogen, alkyl, cycloalkyl, cycloalkyl-alkyl, hydroxy, alkoxy, cycloalkoxy, cyanoalkyl, halo, haloalkyl, haloalkoxy, cyano, amino, nitro, aryl, aryloxy, aryl-alkyl, heteroaryl and/or heteroaryloxy, which aryl, aryloxy, aryl-alkyl, heteroaryl and heteroaryloxy may optionally be substituted one or two times with halo, haloalkyl, haloalkoxy, cyano, amino, nitro and/or a group of the formula R′CONH—, wherein R′ represents hydrogen or alkyl;
• and
• R1 represents
• hydrogen, alkyl, cycloalkyl, cycloalkyl-alkyl, hydroxy, alkoxy, cycloalkoxy, cyanoalkyl, halo, haloalkyl, haloalkoxy, cyano, amino, nitro, aryl or heteroaryl, which aryl or heteroaryl may optionally be substituted one or two times with alkyl, halo, haloalkyl, alkoxy, haloalkoxy, cyano, amino, nitro and/or a group of the formula R′CONH—, R′SO2NH— or (R′SO2)2N—, wherein R′ represents hydrogen, alkyl, cycloalkyl, haloalkyl, alkenyl, phenyl or benzyl;
• or
• a group of formula aryl-alkyl-, aryl-Z-(alkyl)m—, aryl-C≡C—, heteroaryl-Z-(alkyl)m— or heteroaryl-C≡C—, wherein
• m is 0 or 1;
• and
• Z represents O or S;
• and wherein the aryl and heteroaryl may optionally be substituted one or two times with alkyl, halo, haloalkyl, hydroxy, alkoxy, haloalkoxy, cyano, amino, nitro and/or a group of the formula R′CONH—, R′SO2NH— or (R′SO2)2N—, wherein R′ represents hydrogen or alkyl;
• or
• R1 and R2, or R1 and R3, together with the carbon atoms to which they are bound, form a benzo-fused aromatic carbocyclic ring, which benzo-fused aromatic carbocyclic ring may optionally be substituted one or two times with alkyl, cycloalkyl, cycloalkyl-alkyl, hydroxy, alkoxy, cycloalkoxy, cyanoalkyl, halo, haloalkyl, haloalkoxy, cyano, amino, nitro and/or a group of the formula R′CONH—, wherein R′ represents hydrogen or alkyl.