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US 2006/0148780 A1Published application
Diazepanes derivatives useful as ifa inhibitors
AssigneeNovartis AG
InventorsBerndt Oberhauser, Josef Meingassner
Life of this patent
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Abstract
Pharmaceutically active diazepanes, e.g. useful for treating disorders or diseases mediated by LFA-1/ICAM-1, LFA-1/ICAM-2, LFA-1/ICAM-3 or LFA-1/JAM-1 interactions.
Claims10
A compound of formula
- wherein
- R1 is (C1-4)alkyl;
- R2 is unsubstituted (C1-4)alkyl or (C1-4)alkyl substituted by unsubstituted or substituted
- (C6-18)aryl or
- (C6-18)aryl annelated with heterocyclyl having 5 or 6 ring members and 1 to 4 heteroatoms selected from N, O, and S;
- and
- R3 is (C6-18)aryl one or morefold substituted by
- halogen,
- halo(C1-6)alkyl,
- halo(C1-6)alkoxy,
- cyano,
- phenyl, or
- heterocyclyl having 5 to 6 ring members and 1 to 4 heteroatoms selected from N, O, and S.
10 more elements
Dependencies are inferred from the claim text.