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US 2006/0148765 A1Published application
7-Substituted fused ring tetracycline compounds
AssigneeParatek Pharmaceuticals, Inc.
InventorsMark Nelson, Laura McIntyre
Life of this patent
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Abstract
7-substituted fused ring tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted fused ring tetracycline compounds are described.
Claims18
A 7-substituted fused ring tetracycline compound of the formula:
- wherein:
- X is CR6R6′;
- R4 and R4′ are each alkyl;
- R5 is hydrogen, hydroxyl, or a prodrug moiety;
- R6 and R6′ are each independently hydrogen, hydroxyl, alkyl, or taken together, alkenyl;
- Y and Y′ are each independently optionally substituted C, N, O, or S;
- m is 1 or 2;
- and pharmaceutically acceptable salts thereof.
5 more elements
A method for treating a tetracycline responsive state in a mammal, comprising administering to said mammal a 7-substituted fused ring tetracycline compound of formula (I):
- wherein:
- X is CR6R6′;
- R4 and R4′ are each alkyl;
- R5 is hydrogen, hydroxyl, or a prodrug moiety;
- R6 and R6′ are each independently hydrogen, hydroxyl, alkyl, or taken together, alkenyl;
- Y and Y′ are each independently optionally substituted C, N, O, or S;
- m is 1 or 2;
- and pharmaceutically acceptable salts thereof, such that the tetracycline responsive state is treated.
5 more elements
Dependencies are inferred from the claim text.