Amphiphilic macrocyclic derivatives and their analogues
AssigneeUniversity College Dublin
InventorsRaphael Darcy, Lawrence Penkler, Bart Ravoo
Life of this patent
Estimating the term…
Abstract
Soluble amphiphilic macrocycle analogues having lipophilic groups attached to one side of the units making up the macrocycle and hydrophilic groups attached to the other side. These amphiphilic macrocyclic derivatives have the ability to self-assemble in aqueous solvent forming micelles or vesicles and can be used as hosts for the solubilisation and/or stabilisation of various compounds. Embodiments of the present invention utilise macrocyclic oligosaccharides and preferably cyclodextrin as the macrocyclic derivatives to be modified.
Claims36
1-20. (canceled)
An amphiphilic macrocyclic derivative, characterised in that the macrocyclic derivative is a cyclodextrin derivative of the following formula:
- in which n equals 6-8, and indicates the number of modified glucose units in the macrocycle which may be the same or different, depending on the X- and R-groups,
- X1, X2, X3 independently, provide linking groups;
- R1 independently, provide groups which are lipophilic;
- R2 and R3, independently, provide groups which are polar and/or capable of hydrogen-bonding, and are selected from the group comprising:
- (CH2)2-4OH, CH2CH(OH)CH2OH, CH2CH(OH)CH2NH2, CH2CH2NH2, a cation, an anion, sulfonato, any pharmaceutically acceptable ion, and a predominantly hydrophilic group.
33-36. (canceled)
Dependencies are inferred from the claim text.