Regimens for intra-articular viscosupplementation
AssigneeGenzyme Corporation
InventorFrancois Bailleul
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Abstract
The invention provides viscosupplementation methods for treating osteoarthritis and joint injury with HA-based viscosupplements, particularly viscosupplements with an intra-articular residence half-life shorter than 3 weeks. Viscosupplements for use in the methods of the invention may be further characterized in that they contain less than 20 mg/ml HA, at least 5% (w/w) of which is in a gel form, such as, e.g., hylan B. In an illustrative embodiment, hylan G-F 20 (Synvisc®) is administered in a single intra-articular knee injection of 6±2 ml.
Claims35
A viscosupplementation method for treating a knee joint of a subject, the method consisting of a single intra-articular administration of 4 ml or more.
A viscosupplementation method for treating a knee joint of a human subject, the method consisting of a single intra-articular administration of 6±2 ml Synvisc®.
A method of treating osteoarthritic pain in a knee joint of a human subject, the method comprising administering a single intra-articular injection of 6±2 ml Synvisc®.
The method of claim 31, wherein the amount is 6 ml.
A viscosupplementation device, comprising a syringe containing 4 ml or more of Synvisc®.
Dependencies are inferred from the claim text.