Method of treating soild tumors and leukemias using combination therapy of vitamin D and anti-metabolic nucleoside analogs
OwnerCandace Johnson, Donald Trumpinventors
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Abstract
The present invention relates to a method of inhibiting solid tumor cell or leukemia cell proliferation by first administering to a solid tumor cell or leukemia cell either vitamin D or a derivative thereof and subsequently administering at least one anti-metabolic nucleoside analog to the solid tumor cell or the leukemia cell. Also disclosed is a method of treating a cancerous condition. Methods of down regulating a p-AKt survival signaling pathway and modulating activity of a pro-apoptotic caspases is also disclosed.
Claims9
A method of downregulating a p-Akt survival signaling pathway comprising:
- exposing a cell exhibiting a p-Akt survival signaling pathway to a combination of (i) vitamin D or a derivative thereof and (ii) at least one anti-metabolic nucleoside analog, wherein said exposing reduces the activity of the p-Akt survival signaling pathway in said cell.
A method of modulating activity of a pro-apoptotic caspase, said method comprising:
- exposing a cell to a combination of (i) vitamin D or a derivative thereof and (ii) at least one anti-metabolic nucleoside analog, wherein said exposing enhances the activity of a pro-apoptotic caspase in said cell.
Dependencies are inferred from the claim text.