Nucleic acid derivatives
AssigneeBio-Rad Laboratories, Inc.
InventorDavid Segev
Life of this patent
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Abstract
A compound which comprises a backbone having a plurality of chiral carbon atoms, the backbone bearing a plurality of ligands each being individually bound to a chiral carbon atom of the plurality of chiral carbon atoms, the ligands including one or more pair(s) of adjacent ligands each containing a moiety selected from the group consisting of a naturally occurring nucleobase and a nucleobase binding group, wherein moieties of the one or more pair(s) are directly linked to one another via a linker chain; building blocks for synthesizing the compound; and uses of the compound, particularly in antisense therapy.
Claims25
A process of modulating the expression of a gene in an organism, the process comprising administering to said organism a compound which comprises a backbone having a plurality of chiral carbon atoms, said backbone bearing a plurality of ligands each being individually bound to a chiral carbon atom of said plurality of chiral carbon atoms, said ligands including at least one pair of adjacent ligands each containing a moiety selected from the group consisting of a naturally occurring nucleobase and a nucleobase binding group, wherein moieties of said at least one pair are directly linked to one another via a linker chain, such that said compound binds in a sequence specific manner DNA or RNA deriving from said gene.
Dependencies are inferred from the claim text.