Novel treatment of neurodegenerative diseases by altering levels of TrkB isoforms and/or TrkC isoforms
AssigneeUniversity of Maryland
InventorsBruce Krueger, Tami Kingsbury, Linda Bambrick, Susan Dorsey
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Abstract
This invention relates to a method of treating or preventing neuro-degenerative disorders and neuro-developmental disorders by altering the ratio of the amount of full-length TrkB polypeptide to the amount of truncated TrkB polypeptides in a neuron or by altering the ratio of the amount of full-length TrkC polypeptide to the amount of truncated TrkC polypeptides in a neuron.
Claims11
A method of treating a neuro-degenerative disorder or a neuro-developmental disorder, said method comprising:
- contacting a neuropathic hippocampal neuron with an amount of an isolated nucleic acid encoding full-length TrkB or any mutant, variant, homolog, or fragment thereof having the same activity as said full-length TrkB, whereby said amount of said isolated nucleic acid is sufficient to increase the amount of full-length TrkB in said neuron compared to an untreated neuron.
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A method of a neuro-degenerative disorder or a neuro-developmental disorder, said method comprising
- contacting a neuropathic hippocampal neuron with an amount of a vector sufficient to alter the ratio of amount of full-length TrkB polypeptide to truncated TrkB polypeptide in said neuron.
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Dependencies are inferred from the claim text.