DNA-based aptamers for human cathepsin G
OwnerManlio Palumbo, Barbara Gatto +3inventors
InventorsManlio Palumbo, Barbara Gatto, Rodolfo Pescador, Roberto Porta, Laura Ferro
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Abstract
The present research is directed to the identification of non-peptidic inhibitors of cathepsin G characterised by high levels of selectivity and which can be efficaciously used in the treatment and prophylaxis of inflammatory occurrences and procoagulant conditions. The cathepsin G-inhibiting aptamers according to the invention consist of linear DNA or polynucleotide sequences having a chain length of at least 60 nucleotides and being substantially not subjected to undergo efficient base pairing.
Claims13
Cathepsin G-inhibiting aptamers consisting of linear DNA or polynucleotide sequences having a chain length of 70÷120 nucleotides and undergoing inter and/or intra molecular base pairing to an extent lower than 20%, said sequences being characterized by:
- having a molar ratio AG/TC of 1.0÷2.0;
- or
- being (GT)n or (AC)n oligopolymers in which n is in the range from 35 to 60;
- or
- being (T)n or (G)n or (A)n or (C)n or (Inosine)n omopolymers in which n is in the range from 70 to 120.
Dependencies are inferred from the claim text.