Use of cis-epoxyeicosantrienoic acids and inhibitors of soluble epoxide hydrolase to reduce damage from stroke
AssigneesThe Regents of the University of California, Medical College of Georgia
InventorsBruce Hammock, John Imig, Anne Dorrance
Life of this patent
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Abstract
The invention provides uses and methods for reducing brain damage from stroke. The uses comprise the use of an inhibitor of soluble epoxide hydrolase (sEH) for the manufacture of a medicament to reduce brain damage from stroke, as well as the use of cis-epoxyeicosatrienoic acid (EET) for that purpose. The methods comprise the administration of sEH inhibitors to persons who have had a stroke, or who are at risk of having a stroke. Optionally, the methods also include the administration of EETs.
Claims20
A use of an inhibitor of soluble epoxide hydrolase (“sEH”) for the manufacture of a medicament to reduce brain damage from stroke.
A use of a cis-epoxyeicosatrienoic acid (“EET”) for the manufacture of a medicament to reduce brain damage from stroke.
A use of a nucleic acid that inhibits expression of soluble epoxide hydrolase (“sEH”) for the manufacture of a medicament for reducing brain damage from stroke.
A method of reducing brain damage from a stroke, comprising administering an inhibitor of soluble epoxide hydrolase (“sEH”) to a subject who has suffered a stroke.
A method of reducing brain damage from a stroke, said method comprising administering an inhibitor of soluble epoxide hydrolase (“sEH”) to a subject at risk of suffering a stroke.
Dependencies are inferred from the claim text.