Back to results
US 2006/0148742 A1Published application
Polynucleotide delivery to cardiac tissue
OwnerDavid Kaye, John Power +4inventors
InventorsDavid Kaye, John Power, Clifton Alferness, Adam Bilney, Kenneth Chien, Athanasios Preovolos
Life of this patent
Estimating the term…
Abstract
A method for delivering a polynucleotide to cardiac tissue, including substantially isolating the coronary venous circulation from systemic circulation, and introducing a polynucleotide into the isolated coronary venous circulation to effect localized transfection of cardiac tissue. The polynucleotide advantageously produces a therapeutic effect, such as increasing or decreasing the expression level of a protein in the cardiac tissue.
Claims58
A method for delivering a polynucleotide to a cardiac cell in an animal, the method comprising:
- substantially isolating the coronary venous circulation from the systemic circulation of the animal;
- and
- introducing the polynucleotide into the coronary arterial circulation;
- wherein the polynucleotide is substantially prevented from entering the systemic circulation.
1 more element
Dependencies are inferred from the claim text.