Metastasis suppressor gene on human chromosome 8 and its use in the diagnosis, prognosis and treatment of cancer
AssigneeThe Government of the USA, as represented by the Secretary, Department of Health and Human Services
InventorsJ. Barrett, Naoki Nihei, Natalay Kouprina, Vladimir Larionov
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Abstract
The invention provides an isolated or purified ribonucleic acid (RNA) molecule comprising a nucleotide sequence encoded by a human (Tey1) metastasis suppressor gene located at p21-p12 on chromosome 8 or a fragment thereof, wherein the isolated or purified RNA molecule comprises from about 10 to about 100 nucleotides. The invention also provides methods of diagnosis, prognosis, and treatment of cancer, such as prostate cancer, using the isolated or purified RNA molecule.
Claims28
An isolated or purified ribonucleic acid (RNA) molecule comprising a nucleotide sequence encoded by a human (Tey1) metastasis suppressor gene located at p21-p12 on chromosome 8 or a fragment thereof, wherein the isolated or purified RNA molecule comprises from about 10 to about 100 nucleotides.
A method of treating cancer prophylactically or therapeutically in a mammal, which method comprises administering to the mammal an effective amount of an isolated or purified RNA molecule comprising a nucleotide sequence encoded by a human (Tey1) metastasis suppressor gene located at p21-p12 on chromosome 8, or a fragment thereof, wherein the isolated or purified RNA molecule comprises from about 10 to about 100 nucleotides, optionally in the form of (a) a vector or (b) a conjugate, whereupon the mammal is treated for the cancer prophylactically or therapeutically.
A method of diagnosing cancer in a mammal, which method comprises:
- (a) obtaining a test sample from the mammal, and
- (b) assaying the test sample for the level of an RNA molecule comprising a nucleotide sequence encoded by a human (Tey1) metastasis suppressor gene located at p21-p12 on chromosome 8, or a fragment thereof, wherein the RNA molecule comprises from about 10 to about 100 nucleotides, wherein a decrease in the level of the RNA molecule in the test sample as compared to the level of the RNA molecule in a control sample is diagnostic for the cancer.
A method of prognosticating cancer in a mammal, which method comprises:
- (a) obtaining a test sample from the mammal, and
- (b) assaying the test sample for the level of an RNA molecule comprising a nucleotide sequence encoded by a human (Tey1) metastasis suppressor gene located at p21-p12 on chromosome 8, or a fragment thereof, wherein the RNA molecule comprises from about 10 to about 100 nucleotides, wherein an increase in the level of the RNA molecule over time is indicative of a positive prognosis and a decrease in the level of the RNA molecule over time is indicative of a negative prognosis.
Dependencies are inferred from the claim text.