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US 2006/0148737 A1Published application
Wound healing method and kits
AssigneeThe John Hopkins University
InventorJohn Harmon
Life of this patent
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Abstract
Electroporation is used to enhance the wound-healing benefit provided by transfection of nucleic acids that encode cellular growth factors. Wounds which are amenable to the method include inter alia cutaneous lesions, muscular lesions, osseus lesions, burn wounds, and gastrointestinal anastamoses. Kits comprise electrodes and nucleic acids encoding cellular growth factors.
Claims40
A method to promote wound healing in a patient, comprising:
- administering a nucleic acid encoding a growth factor to a patient at a wound site;
- and
- applying an electric field to the wound site in an amount sufficient to increase expression of the encoded growth factor.
A method to promote wound healing in a patient, comprising:
- administering a nucleic acid encoding a HIF 1-α to a patient at a wound site;
- and
- applying between 1 and 20 pulses of between 500 and 2,000 V/cm and between 10 and 1000 microseconds to the wound site, whereby wound healing is stimulated.
A kit for treating wounds, comprising:
- a nucleic acid encoding a growth factor;
- and
- one or more electrodes for applying an electric field to a wound.
Dependencies are inferred from the claim text.