Method of treating tuberculosis
AssigneeThe Board of Trustees of the University of Illinois
InventorsZhaohai Zhu, Scott Franzblau, Gengli Yu, Olga Krasnykh, Dahua Pan, Kanakeshwari Falzari, Baojie Wan, Saweon Hong, Huiwen Liu
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Abstract
Macrolide and ketolides, and compositions containing the same, useful in the treatment of tuberculosis are disclosed. Methods of treating tuberculosis using the macrolides and ketolides, and compositions containing the same, also are disclosed.
Claims23
A method of treating tuberculosis comprising administering a therapeutically effective amount of a macrolide, a ketolide, or a mixture thereof, to an individual in need thereof, wherein the macrolide or ketolide has an MIC vs. M. tuberculosis of about 50 μM or less.
An article of manufacture comprising:
- (a) a packaged composition comprising a macrolide, ketolide, or mixture thereof;
- (b) an insert providing instructions for administration of the packaged composition of (a) to treat tuberculosis;
- and
- (c) a container for (a) and (b).
An article of manufacture comprising:
- (a) a packaged composition comprising a macrolide, ketolide, or mixture thereof;
- (b) a packaged composition comprising a second therapeutic agent useful in a treatment of tuberculosis;
- (c) an insert providing instructions for a simultaneous or sequential administration of (a) and (b) to treat tuberculosis;
- and
- (d) a container for (a), (b), and (c).
A compound selected from the group consisting of a compound disclosed in Table 1 of the specification, a compound disclosed in Table 3 of the specification, a compound disclosed in Table 4 of the specification, and a compound disclosed in Table 5 of the specification.
Dependencies are inferred from the claim text.