Novel podophyllotoxin compositions
OwnerOlivier Lutz, Evgueni Klinski +2inventors
InventorsOlivier Lutz, Evgueni Klinski, Shengmin Li, Valery Alakhov
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Abstract
The present invention discloses compositions comprising podophyllotoxins, analogs thereof, or derivatives thereof, and a surfactant. The invention also discloses a podophyllotoxin composition further comprising a targeting moiety. The present invention also discloses a method of delivering a podophyllotoxin, an analog thereof or a derivative thereof, to a cell by administering the described podophylootoxin compositions. Further, the present invention discloses a method of making the podophyllotoxin compositions.
Claims24
A fluid pharmaceutical composition comprising an aqueous dispersion of micelles having an average diameter less than about 300 nm, said micelles comprising:
- (i) a podophyllotoxin selected from the group consisting of etoposide and teniposide, and (ii) a surfactant consisting essentially of the covalently linked reaction product of tocopherol and a water-soluble polymer and being at least 99% free of unreacted tocopherol.
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A method of treating an animal comprising administering to the animal a fluid pharmaceutical composition comprising an aqueous dispersion of micelles having an average diameter less than about 300 nm, said micelles comprising:
- a podophyllotoxin selected from the group consisting of etoposide and teniposide, a surfactant consisting essentially of the covalently linked reaction product of tocopherol and a water-soluble polymer and being at least 99% free of unreacted tocopherol.
A method of delivering a podophyllotoxin selected from the group consisting of etoposide and teniposide to a cell comprising administering to the cell a fluid pharmaceutical composition comprising an aqueous dispersion of micelles having an average diameter less than about 300 nm, said micelles comprising:
- a podophyllotoxin selected from the group consisting of etoposide and teniposide;
- and a surfactant consisting essentially of the covalently linked reaction product of tocopherol and a water-soluble polymer and being at least 99% free of unreacted tocopherol.
A method of inhibiting cancer comprising administering to an animal having cancer a fluid pharmaceutical composition comprising an aqueous dispersion of micelles having an average diameter less than about 300 nm, said micelles comprising:
- a podophyllotoxin selected from the group consisting of etoposide and teniposide;
- and a surfactant consisting essentially of the covalently linked reaction product of tocopherol and a water-soluble polymer and being at least 99% free of unreacted tocopherol.
Dependencies are inferred from the claim text.