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US 2006/0148719 A1Published application
Tripeptide and tetrapeptide sulfones
AssigneeTelik, Inc.
InventorSteven Schow
Life of this patent
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Abstract
Tripeptide and tetrapeptide sulfones, pharmaceutical compositions containing them, their pharmaceutical use, and their preparation. The compounds are useful in potentiating the cytotoxic effects of chemotherapeutic agents in tumor cells, selectively exerting toxicity in tumor cells, elevating the production of GM progenitors in bone marrow cells, stimulating the differentiation of bone marrow, mitigating the myelosuppressive effects of chemotherapeutic agents, and modulating hematopoiesis in bone marrow.
Claims25
A compound of the formula
- where:
- X is L-γ-glutamyl or L-γ-glutamylglycyl;
- Y is H, optionally substituted alkyl, optionally substituted heteroalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, or optionally substituted heteroaralkyl;
- and
- Z is C5-9 alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, or optionally substituted heteroaralkyl;
- or its C1-10 alkyl, phenyl-C1-3 alkyl, or (C5-6 heteroaryl)-C1-3 alkyl mono- or di-ester;
- or a salt of the compound or its mono- or di-ester.
4 more elements
Dependencies are inferred from the claim text.