C5a receptor
AssigneeHuman Genome Sciences, Inc.
InventorsYi Li, Craig Rosen
Life of this patent
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Abstract
A human C5a receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for identifying antagonists and agonists to such polypeptide. Antagonists and agonists may be used therapeutically to inhibit or stimulate the C5a receptor. Also disclosed are diagnostic methods for detecting mutations in the polynucleotides of the present invention and for detecting levels of the soluble polypeptides in samples derived from a host.
Claims19
An isolated polynucleotide comprising a member selected from the group consisting of:
- (a) a polynucleotide encoding the polypeptide comprising amino acid 1 to 355 as set forth in SEQ ID NO:2;
- (b) a polynucleotide encoding a mature polypeptide encoded by the DNA contained in ATCC Deposit No. 75821;
- (c) a polynucleotide encoding a polypeptide expressed by the DNA contained in ATCC Deposit No. 75821;
- (d) a polynucleotide fragment of the polynucleotide of (a) or (b) or (c).
A receptor polypeptide comprising a member selected from the group consisting of:
- (a) a polypeptide having the deduced amino acid sequence of SEQ ID NO:2 and fragments, analogs and derivatives thereof;
- and
- (b) a polypeptide encoded by the cDNA of ATCC Deposit No. 75821 and fragments, analogs and derivatives of said polypeptide.
Dependencies are inferred from the claim text.