VEGF-binding fusion proteins and therapeutic uses thereof
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsThomas Daly, James Fandl, Nicholas Papadopoulos
Life of this patent
Estimating the term…
Abstract
Nucleic acid molecules encoding fusion proteins which bind and inhibit vascular endothelial growth factor (VEGF). The VEGF-binding fusion proteins are therapeutically useful for treating VEGF-associated conditions and diseases, and are specifically designed for local administration to specific organs, tissues, and/or cells.
Claims11
An isolated nucleic acid molecule encoding a fusion protein which binds and inhibits VEGF consisting of components (R1R2)X, wherein X≧1, R1 is vascular endothelial cell growth factor (VEGF) receptor component Ig domain 2 of Flt-1 and R2 is Ig domain 3 of Flk-1.
Dependencies are inferred from the claim text.