Sustained delivery of PDGF using self-assembling peptide nanofibers
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsRichard Lee, Patrick Hsieh
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Abstract
The present invention is directed to a therapeutic composition in which human PDGF is bound directly to peptides that self assemble into a biologically compatible gel. When implanted in a patient's body, the composition provides for the slow, sustained release of PDGF. The composition will be especially useful in treating patients who have undergone a myocardial infarction.
Claims20
A biologically compatible peptide membrane comprising self-assembling peptides wherein:
- (a) said peptides are 12-200 amino acids in length, have alternating hydrophobic and hydrophilic amino acids, are complementary and are structurally compatible;
- and
- (b) at least 0.1% of the self-assembling peptides are bound directly to PDGF.
A pharmaceutical composition comprising self-assembling peptides and human PDGF in a pharmaceutically acceptable liquid medium in which the concentration of monovalent metal cation is insufficient to promote the self-assembly of said peptides and wherein there is at least 1 PDGF molecule present for every 1000 peptides.
Dependencies are inferred from the claim text.