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AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsDaria Mochly-Rosen, Rachel Bright
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Methods of increasing blood flow in a mammalian brain blood vessel characterized by, or otherwise experiencing, decreased blood flow due to an ischemic or other hypoxic event, vasoconstriction or vasospasm following hemorrhagic stroke; due to chronic high blood pressure; and/or due to idiopathic causes are provided. The method for increasing blood flow in such a mammalian brain blood vessel includes administering to a patient in need thereof a therapeutically effective amount of an inhibitor of δ protein kinase C. In certain embodiments, the inhibitor can be chronically administered without causing desensitization of the patient to the inhibitor. Kits for increasing blood flow in a mammalian brain blood vessel characterized by, or otherwise experiencing, decreased blood flow due to an ischemic or other hypoxic event, vasoconstriction or vasospasm following hemorrhagic stroke; due to chronic high blood pressure; and/or due to idiopathic causes are provided.
A method of increasing blood flow in a mammalian brain blood vessel experiencing decreased blood flow, comprising administering to a patient in need thereof a therapeutically effective amount of an inhibitor of δ protein kinase C (δPKC).
A kit for increasing blood flow in a mammalian brain blood vessel experiencing decreased blood flow, comprising an inhibitor of δPKC and instructions for using said inhibitor to increase blood flow in said blood vessel.
Dependencies are inferred from the claim text.