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OwnerDaria Mochly-Rosen, Masashi Tanaka +1inventors
InventorsDaria Mochly-Rosen, Masashi Tanaka, Robert Robbins
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Methods for reducing injury to a transplanted mammalian organ or tissue, including inhibiting the development of graft blood vessel disease, are provided. In one form, a method includes administering compositions that include one or more PKC regulators to an organ or tissue donor and an organ or tissue recipient. Methods for decreasing or otherwise modulating an inflammatory response in a mammal are also provided. In one form, a method includes administering one or more regulators of protein kinase C to a patient in need thereof prior to, during or after an event giving rise to an inflammatory response. Methods for inhibiting, or otherwise modulating, a pro-apoptotic event are also provided. In one form, a method includes administering a therapeutically effective amount of an agonist of ε protein kinase C, and optionally an inhibitor of δ protein kinase C.
A method of reducing injury to a transplanted mammalian organ or tissue, comprising:
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The method of claim 7, wherein said inhibitor has an amino acid sequence having at least about 50% identity to the amino acid sequence of δV1-1 set forth in SEQ ID NO:15, at least about 50% identity to the amino acid sequence of δV1-2 set forth in SEQ ID NO:16, or at least about 50% identity to the amino acid sequence δV1-5 set forth in SEQ ID NO:17, or a combination thereof.
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A method of inhibiting development of graft disease in a mammalian blood vessel, comprising:
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A method of decreasing an inflammatory response in a mammal, comprising:
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A method of inhibiting a pro-apoptotic event in a mammal, comprising:
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Dependencies are inferred from the claim text.